A hemostatic criteria for diagnosis of disseminated intravascular coagulation (DIC) based on pathological evidences
スポンサーリンク
概要
- 論文の詳細を見る
The existence of inconsistency between clinical and pathological diagnosis of DIC has been pointed out by many authors. Present study was undertaken to clarify this difference and to establish a reliable hemostatic criteria for diagnosis of DIC. A retrospective analysis was done by the investigation of twenty-six autopsies out of 64 cases with DIC which had been clinically diagnosed in our laboratory of Kyushu University School of Medicine from November, 1972 to May, 1979. There were seen malignancies in 22 (85%) and severe infections in 19 (73%), and combination of both diseases in 13 cases (50%) as the underlying diseases of this series. These cases were divided into two groups according to the presence of multiple fibrin thrombi as the pathological evidence of DIC. Microthrombi were detected in 14 cases (Group A), but not in 12 cases (Group B).Decrease of platelet counts, plasminogen and antithrombin-III levels, prolongation of prothrombin time and serial thrombin time, increase of fibrin degradation products (FDP) levels and positive ethanol gelation test were seen in both groups. In these parameters, a significant difference in both groups was seen in only FDP levels, i. e. mean values were 88 and 36μg/ml respectively. In addition, microthrombi were not often detected when a hemostatic criteria of depleted platelet counts less than 100, 000/mm3, increased FDP levels more than 40μg/ml and positive ethanol gelation test are satisfied. Therefore, such a strict criteria shold be recommended in order to make a clinical diagnosis coincidental to pathological evidence of DIC.
- 一般社団法人 日本血栓止血学会の論文
一般社団法人 日本血栓止血学会 | 論文
- 日本人のＡＤＡＭＴＳ１３
- Infection of specific strains of Streptococcus mutans exacerbated intracerebral hemorrhage
- Transcriptional regulation of megakaryopoiesis and thrombopoiesis
- 新規血小板活性化受容体ＣＬＥＣ－２ その発見から今後の展望まで:その発見から今後の展望まで
- １．臨床血栓止血学オーバービュー