Anti-platelet activity of ST-2, an unsaponifable substance in soybean oil-role of plant sterol, one of the components of ST-2

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ST-2, an unsaponifable substance in soybean oil, is composed of plant sterol, natural tocopherol and unsaturated fatty acids. The authors have reported that administration of ST-2 decreased platelet aggregability in patients with essential hyperlipemia without concomitant improvement in hyperlipemia. Among the constituents of ST-2, tocopherol and linolic acid have been known to have an anti-platelet activity, but plant sterol has not been studied on the effect to platelet aggregation. The present study was carried out to clarify if plant sterol has an anti-platelet activity or not.Human platelet-rich plasma was incubated with natural tocopherol or plant sterol and the changes in platelet sensitivity to ADP-aggregation was assessed.1) Sensitivity of platelets incubated with 0.4mg/ml natural tocopherol dissolved in 2mg/ml bovine serum albumin (BSA) for 15 minutes decreased significantly (P<0.005) as compared with platelets incubated with 2mg/ml BSA, the vehicle of tocopherol.2) Sensitivity of platelets incubated with 1mg/ml plant sterol dissolved in 2mg/ml BSA decreased significantly as compared with platelets incubated with BSA (15 minutes' incubation: P<0.05, 25 minutes' incubation: P<0.005).The results suggest that the inhibitory effect of ST-2 on platelet aggregability in vivo may be attributable not only to tocopherol and linolic acid but also to plant sterol.
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