Morphological studies on tissue thromboplastin in coagulation process
スポンサーリンク
概要
- 論文の詳細を見る
Tissue thromboplastin (T. Tbp) plays an important part in inducing the pulmonary microthrombo-embolism. We have studied the ultrastructures of T. Tbp to demonstrate how it changes during coagulation.[Materials and Methods] T. Tbp from lungs of rabbits, lyoplastin (Mochida Ltd.), was used for these studies. Lyoplastin was injected into ear vein of rabbits. Lungs were resected at several seconds, 10sec, 1min, 5min, 24hrs, 48hrs or 1 week after the injection.The specimens were fixed in phosphate buffered formalin, followed by post-fixation in osmium tetroxide solution. They were examined by transmission electron microscope.[Results] Concentrically arranged membrane structures of the injected T. Tbp disappeared in extremely short time after the injection. 1 min after the injection, the fibrin fibers were seen between single sheet of membrane and endothelial cells of capillaries. In the rabbit which had died suddenly after the injection of T. Tbp, multiple pulmonary thrombi made of fibrin and platelets were seen in capillaries. The endothelial cells of capillaries were destroyed and interstitial tissues were edematous. At 24hrs after the injection, no fibrin-thrombi were seen in capillaries, while endothelial cells were degenerated in some capillaries. It was suggested that multiple pulmonary fibrin-thrombi had been resolved in 24hrs. Type B alveolar epithelial cells seemed to lose their lamellar inclusion bodies in rather short time after the injection and the vacuolization of the lamellar inclusion bodies progressed till 1 week or more after the injection.Thus, the injection of T. Tbp in rabbits brought remarkable injuries in pulmonary capillaries and surrounding tissues.
- 一般社団法人 日本血栓止血学会の論文
一般社団法人 日本血栓止血学会 | 論文
- 日本人のＡＤＡＭＴＳ１３
- Infection of specific strains of Streptococcus mutans exacerbated intracerebral hemorrhage
- Transcriptional regulation of megakaryopoiesis and thrombopoiesis
- 新規血小板活性化受容体ＣＬＥＣ－２ その発見から今後の展望まで:その発見から今後の展望まで
- １．臨床血栓止血学オーバービュー