Comparison of the gastric emptying results among the 13C-octanoic acid breath tests, scintigraphy, and acetaminophen method
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The <SUP>13</SUP>C-octanoic acid breath test has been thought to be one of the most important methods in gastric emptying, because it is non-invasive and needs no special device. In this study, we evaluated the gastric emptying results between the <SUP>13</SUP>C-octanoic acid breath tests, scintigraphy, and acetaminophen method. Ten patients with non-ulcer dyspepsia and 4 healthy volunteers were studied. For the test meal, we used scrambled egg, white bread, and 150 ml water and into the scrambled egg, 100 mg of <SUP>13</SUP>C-octanoic acid, 37 MBq 99mTc-DTPA, and 20 mg/kg body weight of acetaminophen were mixed. After eating, breath samples and scanning scintigraphic information was obtained up to 8 and 2 hours, respectively. Blood sample was obtained 45 minutes after eating and the concentration of serum acetaminophen were measured. Previously, a positive correlation between the half emptying time (t<SUB>1/2</SUB>) determined by breath test and scintigraphy, was reported by Ghoos <I>et al</I>.(1993) (y=1.12x+66.1, R<SUP>2</SUP>=0.79, p<0.0001) and in this study a positive correlation was found (y =0.76x +113, R<SUP>2</SUP>=0.29, p=0.047). There was a negative correlation between the t, 12 determined by scintigraphy and the concentration of serum acetaminophen (y=-0.12x+15.9, R<SUP>2</SUP>=0.40, p=0.013). In case of that <SUP>13</SUP>CO<SUB>2</SUB> excretion of breath test was remained, even 8 hours after eating, t<SUB>1/2</SUB> and lag phase determined by breath test were more delayed than actual state. In case of that <SUP>13</SUP>CO<SUB>2</SUB> excretion curve in early phase was drawn like sigmoid curve, t<SUB>1/2</SUB> determined by breath test were more delayed than actual state. In case of that <SUP>13</SUP>CO<SUB>2</SUB> excretion curve had two peak-points, there was no problem. In conclusion the <SUP>13</SUP>C octanoic acid breath test is a promising and reliable method for measuring gastric emptying.
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