Clinical and Endoscopic Studies on 87 Patients with Drug-Induced Gastrointestinal Disorders.

スポンサーリンク

概要

• 論文の詳細を見る

• The studied subjects were 87 patients with drug-induced mucosal lesions in gastrointestinal (GI) tract, who were seen in our clinic for the past 10 years. Patient's ages ranged from 13 to 80 years (median, 52yr). 40 patients were male and 41 female. They included 7 patients with esophageal lesions, 58 with gastric lesions, 4 with duodenal lesions and 18 with eolonic lesions. The common drugs involved in upper GI tract lesions, were nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, antibiotics, tranquilizers, potassium chloride, antineoplastic drugs and combination of them. The lower GI tract lesions were two kinds of antibitic-associated colitis, pseudomembranous colitis and acute hemorrhagic colitis. A major facto-producing esophageal injury was long-term retention of causative agents in the lower esophagus due to postoperative rest in bed and/or intake of drugs without water. Drug-induced gastric lesions had various characteristic features, and were common in old aged woman. Most of them had orthopedic disorders such as rheumatoid arthritis, bone fractures and other diseases with neuralgia. Endoscopic features with drug-associated ulcers were multiple, irregular formed and hemorrhagic. Occasionally single trench ulcer was found. AGML with severe symptoms such as hematoemesis, severe epigastralgia was found in 30% in patients with drugassociated gastric lesions. In antibiotic-associated colitis, pseudomembranous colitis were more frequent in older people, which developed after administrations of cephem-family antibiotics in 50% of the patients. On the other hand, acute hemorrhagic colitis were common in young people, and 61% of them received penicillin-family antibiotics. The periods from drug intake to onset of the disorders were within a week in esophageal ulcer and AGML, within 2 weeks in duodenal ulcer and antibiotic-associated colitis, and over a month in gastritis and gastric ulcer respectively. Emergent endoscopy should be performed to confirm the diagnosis of drug-induced GI mucosal lesions, and the administration of causative agents should be stopped as early as possible.

• 社団法人 日本消化器内視鏡学会の論文

社団法人 日本消化器内視鏡学会 | 論文

• 経皮内視鏡的胃瘻造設術を受けた患者における生存期間と栄養評価の関係
• 内視鏡的バルーン拡張術にて治療しえたPlummer-Vinson症候群の2例
• 糖尿病に合併した急性壊死性食道炎の1例
• 内視鏡的経鼻膵管ドレナージとオクトレオチドが有効であった膵性胸水の1例
• 重症急性膵炎後膵膿瘍に対し超音波内視鏡ガイド下ドレナージ術が有効であった1例

もっと見る

スポンサーリンク