A CASE OF INTESTINAL BEHCET'S DISEASE (SUSPECTED) SHOWING ONLY APHTOID ULCERS THROUGHOUT THE COLON FOR A LONG PERIOD

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A 34- year-old man visited our hospital with conplaints of fever, diarrhea, sore throat and oral aphtoid ulcer in March 1985. Laboratory findings revealed inflammatory sign and mild anemia. Barium enema and colonoscopy showed multiple aphtoid ulcers throughout the colon. Microscopic examination of the biopsied specimens from the aphtoid ulcers disclosed non-specific inflammation. The patient was treated with elental diet, intravenous hyper alimentation and salazosulfapyridine. But the aphtoid ulcers did not disappear. In February 1988, barium enema and colonoscopy showed enlarged aphtoid ulcers, and UGI endoscopy showed a pharyngeal ulcer. Therefore, he was treated with predonisolone and later cyclophosphamide. In April 1989, barium enema and colonoscopy showed disappearance of the aphtoid ulcers, but showed an irregular ulcer in the cecum at that time. After continuation of the same therapy, barium enema in July 1990 showed disappearance of the cecal ulcer. From appearance of oral aphtoid ulcer, cecal ulcer and positive HLA B-51 test, the most suspicious diagnosis of this case is intestinal Behcet's disease.
社団法人日本消化器内視鏡学会の論文