Cell proliferation kinetics of regenerative epithelium in refractory gastric ulcers.
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概要
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In order to study the cell proliferation kinetics of regenerative mucosa of refractory gastric ulcer, m<SUP>3</SUP>H-thymidine autoradiography was conducted by using biopsy tissues sampled endoscopically. As for labeling index determined by the ratio of number of labeled cells/number of epithelial cells of gastric mucosa, the refractory cases presented high values, the same as the tractable cases, in the endoscopic stages A<SUB>2</SUB>, H<SUB>1</SUB>, H<SUB>2</SUB>, and histological classification (H<SUB>2</SUB>, H<SUB>3</SUB> : Yoshii's classification) H<SUB>2</SUB>, H<SUB>3</SUB> tufty (+) stage, but the values were low in the S<SUB>2</SUB> stage and H<SUB>3</SUB> tufty (-) stage. Between the refractory cases and tractable cases, there was no histological difference in the regenerative epithelium. Between the group administered histamine H<SUB>2</SUB>-receptor antagonists and the group not administered, there was no difference in the changes of labeling index whether in the healing stage or in the scarring stage. It is hence known that the cell proliferation is active in the regenerative mucosa even in refractory ulcer, and the cause of refractory ulcers, it seemed necessary to consider other factors than morphological or functional changes of the regenerative epithelium. Besides, the histamine H<SUB>2</SUB>-receptor antagonists did not promote the cell proliferation kinetics of the regenerative epithelium, and the effect of this agent seemed to be limited if attempted to heal the ulcer by encouraging the cell proliferation kinetics.
- 社団法人 日本消化器内視鏡学会の論文
社団法人 日本消化器内視鏡学会 | 論文
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