Endoscopic follow-up and mucosal cell kinetics of drug induced gastric lesion in the experimental models.

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The relationships between the endoscopic finding and the alteration of mucosal cell kinetics and gastric mucosal blood flow (GMBF) were evaluated in the canine stomach with mucosal lesion induced by chronic administration of aspirin and ACNU (anticancerous agent). A charateristic pattern in the alteration of mucosal cell kinetics such as an initial suppression and a following recovery was demonstrated when mucosal lesion developed. The formation of mucosal lesion and the adaptating process were more closely related with cell kinetic alteration than with GMBF, because the mucosal lesion observed by endoscopy became severe after an initial suppression of mucosal cell kinetics and gradually remitted after a recovery of cell kinetics to the normal level in spite of the continuation of drug administration.
社団法人日本消化器内視鏡学会の論文