CLINICAL STUDY OF THREE CASES OF CRONKHITE-CANADA SYNDROME

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A 71-year-old male referred to our hospital because of anal bleeding. Polyposis throughout the colon was found by colonoscopy. After the nutritional therapy, diarrhea was developed and the ectodermal changes rapidly deteriorated. Clinical course and effect of the therapy were studied on above-mentioned case and the other two followed-up cases of Cronkhite-Canada syndrome (CCS) since 1981.(1) The initial symptoms were hypogeusia and anorexia. (2) It is suggested that polyposis might be proceded prior to the ectodermal changes. (3) The patients, condition gradually deteriorated during the follow-up period.Though the clinical status was slightly improved in one case by the nutritional control, the additional steroid therapy was needed for all cases to improve markedly the disease process. (4) In one case, the steroids has been administered for eleven months and then polyposis recurred after stopping the steroids for three months. (5) Investigation of the malignant lesion may be necessary since the gastric cancer was complicated in one case and the adenomas of the colon were observed in two cases.
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