THERAPEUTIC EFFECT OF SALICYLAZOSULFAPYRIDINE IN CROHN'S DISEASE
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概要
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Salicylazosulf apyridine (SASP) in a single dose of Z to 4g was administered to 9 patients with untreated Crohn's disease to evaluate its therapeutic effect. The effect was judged using the criteria compiled by the Investigation and Research Committee for Inflammatory Bowel Disease organized by the Ministry of Health and Welfare. Changes in the X-ray and endoscopic findings were simultaneously investigated. Results showed that the SASP therapy was remarkably effective in 5 but ineffective in 4 of the 9 patients. In one of the 5 cases in which the drug was effective, the lesions disappeared, as shown by X-ray and endoscopic examination, with the use of SASP alone. There was also objective improvement as shown by X-ray and endoscopic examination in the remaining 4 cases, but the lesions still remained. These lesions disappeared after treatment with a combination of SASP and elemental diet. As the cases in which SASP was effective were those with Crohn's disease accompanied by colonic involvement, it is suggested that SASP is effective in cases of Crohn's disease of both the small and large intestine and in Crohn's colitis. Despite the disappearance of the subjective symptoms and normalization of the ESR and CRP values due to SASP therapy, there were many cases with lesions indicated by the X-ray and endoscopic examinations. Combination therapy with elemental diet was thus thought to be desirable in such cases.
- 社団法人 日本消化器内視鏡学会の論文
社団法人 日本消化器内視鏡学会 | 論文
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