Effects of xylazine on gastrointestinal motility in goats and dogs.
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概要
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The effects of xylazine on gastrointestinal motility in conscious goats and dogs were studied by using strain gauge force transducers and bipolar electrodes. Vomiting induced by xylazine in the dog was also observed under feeding, drugs injections or vagotomy.<BR>1) Continuous activity and no activity for a short period in the abomasum, and migrating myoelectric complex (MMC) in the small intestine were observed cyclically in the goat.<BR>2) Digestive and interdigestive contractions in the gastrointestine were observed in the dog.<BR>3) Contractile and electrical activity continued in the antrum of the goat after xylazine injection but were restricted in other parts of the antrum.<BR>4) Vomiting induced by xylazine was observed in the dog with full stomach more than that with empty one. The reflex of vomiting were not inhibited completely by pretreatments of atropine and propionylpromazine, though phentoramine and yohimbine inhibited the phenomenon.<BR>5) Antiperistaltic contractile and electrical activity from the lower part of the small intestine in the dog were observed before vomiting, and dysrhythmia of the basic electrical rhythm (BER) was also observed before and after vomiting following xylazine injection.<BR>The results indicated that the affecting site of xylazine is the central nervous system (CNS) and that its actions are revealed by excitation of a2-adrenoceptor. Furthermore, the results suggested that the impulse to vomit is transmitted not only to the vagus but also outside the vagus.
- 獣医麻酔外科学会の論文
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