Effects of flunitrazepam-ketamine mixed injection for inhalation induction.

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Experiments were performed to investigate the effects of inhalation induction in dogs. The combination is preceded by administration of 0.025 mg/kg of atropine sulfate subcutaneously. The dosage is 0.1 mg/kg of flunitrazepam and 5 mg/kg of ketamine, administered intravenously mixed in one syringe. The results were as follows :<BR>1. Jaw reflex and auricular reflex were cd not disappear completely but intubation was performed easily. 2. Decrease of arterial blood pressure was controlled in comparison with flunitrazepam administration alone.<BR>3. Less obvious changes in electrocardiogram were found in it.<BR>4. Immediately after administration, respiration rate and arterial oxygen tension were slightly decrease, therefor using it, in advance anesthesia, great care and inhalation oxygen must be taken.<BR>5. The above : It was suggested that flunitrazepam and ketamine administered intravenously mixed injection were useful means.
獣医麻酔外科学会の論文