EFFECT OF 50% NITROUS OXID AND 50% OXYGEN PREMIXED GAS (ANESOXYN-50) ON BLOOD GASES AND THE RELATED CLINICAL FINDINGS EXPERIMENTAL ANIMALS

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The efiects of 50% Nitrous oxide and 50% Oxygen premixed gas were examined clinically, hematologically and blood-chemically in dogs of experimental group (I) premedicated iv. with Atropine salfate and the group (II) premedicated iv. together with Atropine salfate and Combelen. Other animal species were premedicated with Atropine salfate. From the result of the inhalation of Anesoxyn-50, it was not useful for the anesthesia in all examined animals. But it was effective for hypnosis in dogs, and also in cats and cynomologus monkeys the hypnosis was produced at first 5 to 15 mintes during the inhalation. In mice and small birds, it was no effective for hypnosis. Hematocrit decreased significantly at 20 minutes during the inhalation in group I as compared with that observed before inhalation. Heart rate decreased significantly at 20 minutes during the inhalation in group II. PO2 increased significantly in two groups and as weell PaO2 increased particularly. Furthermore, PaCO2 increased significantly at 50 minutes during the inhalation in group II. Although blood glucose increased only by the stimulation of setting gas mask with the animals, it rised moreover at 20 minutes during the inhalation in group II. Toxic important factors were not observed clinically from this study.
獣医麻酔外科学会の論文