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We report a familial occurrence of cardiac sarcoidosis. Case 1 (elder sister) was diagnosed as having sarcoidosis with mediastinoscopy at 73 years old. One year and 3 months later she was found to have CRBBB on an ECG, thinning of the basal portion of the ventricular septum and asynergy on an echocardiogram, and non-sustained VT on a Holter ECG. Although she was diagnosed as having cardiac sarcoidosis, we could not get her consent to do corticosteroid therapy and continue to follow her case. Case 2 (younger brother) was diagnosed as having sarcoidosis with mediastinoscopy at 61 years old. Two years and 5 months later he was found to have CRBBB on an ECG and asynergy on an LVG. We started to administer corticosteroids, but 3 months later he had sustained VT and needed electric defibrillation. At the same time, he had thinning of the basal portion of the ventricular septum and a dilated left ventricle, with a decrease of left ventricular ejection fraction. We diagnosed him as having cardiac sarcoidosis and we increased the dose of corticosteroids and implanted an ICD. But, while tapering off the dose of corticosteroids, the ICD activated due to a VT attack. To prevent VT attack the patient is being treated with Amiodaron.
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