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We evaluated the clinical features of 32 sarcoidosis cases associated with asthma. In our clinic, 32 (10.6%) of the 301 sarcoidosis patients (108 male, 193 female, average observation period 7.5±4.2 years) had asthma. The association was found more frequently in females (25 cases-13.0%) than in males (7 cases-6.5%). The stage of chest X-ray and age-sex distribution were the same between those with and without asthma. Asthma appeared in 6 cases before sarcoidosis and in 26 cases after sarcoidosis: 7 cases in 2 years, 8 cases after 3-5 years, 8 cases after 6-9 years and 3 cases after 10 years or more. Asthma was diagnosed in 19 cases (17.9%) of the 106 cases whose sarcoidosis deteriorated or remained unchanged, and in 7 cases (3.7%) of the 189 cases whose sarcoidosis improved. From the present molecular-biological view, sarcoidosis is a Th1 disease, while asthma is a Th2 disease and we expected the two diseases might show a reversed trend. However, our experiences revealed that asthma occurred during the periods of either improvement or deterioration of sarcoidosis.
- 日本サルコイドーシス/肉芽腫性疾患学会の論文
日本サルコイドーシス/肉芽腫性疾患学会 | 論文
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