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The risk of cancer following sarcoidosis has long been an issue argued over but no conclusion has so far been drawn.We found 19 patients diagnosed as having malignant tumors following sarcoidosis among the 355 sarcoidosis patients visiting Okayama University Hospital. They are classified into 14 types and 25 malignant tumors. Among them, 7 lung cancer cases were found. The average observation period from the diagnosis of sarcoidosis to the detection of lung cancer was 9.7 years (1.8-15.7 years). And the average age at the onset of the lung cancer was 68 years old (38-78 years old), being older than the national average.We calculated the relative risk of malignant tumors based on the 355 patients with sarcoidosis for a total of 3, 340 personyears. The observed number of lung cancer cases was 7 per 100, 000 with the relative risk being 2.45 times (p<0.05) higher, than the expected number (2.86 per 100, 000 people).As sarcoidosis appears to increase the risk of lung cancer, careful observation of sarcoidosis patients may be needed.
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