Clinical features in elderly patients with sarcoidosis

概要

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Sarcoidosis, a chronic granulomatous disease, usually affects young adults and is believed to be rare in the elderly. To clarify the clinical features in elderly patients with sarcoidosis, we reviewed the medical records of 56 patients with sarcoidosis including 41 biopsy-proven cases and 15 clinically-diagnosed cases. Elderly patients who are over 65 years old were 15 cases. In the elderly patients, a female predominance was noted, as well as more frequent respiratory and ocular symptoms. Chest X-ray demonstrated most patients irrespective of the age presented with hilar or mediastinal lymphadenopathy only (stage I) and hilar or mediastinal lymphadenopathy with pulmonary parenchymal diseases (stage II). We further evaluated hilar and mediastinal lymphadenopathy and parenchymal abnormalities with high-resolution computed tomography (HRCT). There were no differences in the size of hilar and mediastinal lymphadenopathy between the elderly and younger patients. In contrast, ground-glass opacities were significantly more frequent and consolidation tended to be more common in elderly patients than in younger patients. In conclusion, elderly patients with sarcoidosis tend to be female having more respiratory and ocular symptoms, and presented with ground-glass opacities and consolidation on HRCT.
日本サルコイドーシス/肉芽腫性疾患学会の論文