Clinical Evaluation of Endotoxin Adsorption Therapy for Postoperative Septic Patients
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概要
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In 88 cases treated with polymyxin B immobilized fiber with direct hemoperfusion (PMX-DHP), changes in hemodynamics, pulmonary oxygenation (PaO2/FIO2) and various cytokine levels (TNF-α, IL-6, IL-8, IL-ra, and IL-10) were examined separately accordingly to patient outcome (64 survivors and 24 deaths). All patients received urgent operations for the treatment of intra-abdominal infections. In the survival group, the PaO2/FIO2 tended to improve as the blood pressure increased. The mechanism responsible for the improvement in pulmonary oxygenation in response to PMX-DHP remains uncertain and requires further clarification. The PAI-1 values decreased in the survivor group immediately after PMX-DHP, while the ICAM-1 and ELAM-1 values tended to decrease in both groups. The PAI-1 value may be a useful clinical parameter for predicting PMX-DHP efficacy.
- 日本腹部救急医学会の論文
日本腹部救急医学会 | 論文
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