Decreased Response to Growth Hormone after Interruption of Therapy
スポンサーリンク
概要
- 論文の詳細を見る
The relatively high cost of recombinant human growth hormone (rhGH) has raised the issue of whether intermittent treatment regimens might be efficacious for patients with GH deficiency. Two previous reports have suggested that interruption of GH treatment may avoid the typical waning of response associated with continuous GH therapy and may, therefore, result in an advantageous cost-benefit ratio. We have studied 2 patients with GH deficiency treated with rhGH which was interrupted for one month. The one month of interrupted therapy did not have any beneficial effect and may have caused a loss of potential growth. Although our observations are limited, the data indicate that intermittent GH treatment regimens should not be advocated in the absence of additional investigations.
- 日本小児内分泌学会の論文
日本小児内分泌学会 | 論文
- 43 Common origin of the Q258X mutation in StAR gene responsible for congenital aderenal lipoid hyperplasia in Japanese
- Recent Change in the Annual Incidence of Childhood Type 2 Diabetes in the Tokyo Metropolitan Area
- A Case of Acute Lymphoblastic Leukemia with Prader-Willi Syndrome during Growth Hormone Therapy
- Characteristics of a Fulminant Onset Form of Idiopathic Type 1 Diabetes Mellitus in Japanese Children
- Different Skeletal Phenotypes in a Mother and Two Daughters with Short Stature Homeobox-Containing Haploinsufficiency