Immunoenhancement through Growth Hormone Treatment
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概要
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Growth hormone (GH) and insulin-like growth factor I (IGF-I) have immunostimulatory effects in addition to their anabolic action. In this review the immunoenhancing effects of exogenous anabolic hormones will be described according to our findings in a bacterial peritonitis model. Pretreatment with GH (0.48 or 4.8 mg/kg/day) or IGF-I (24 mg/kg/day) increased the survival time in a murine model of <I>Escherichia coli (E. coli)</I> peritonitis. In addition, the numbers of peritoneal exudative cells in the GH-and IGF-I-treated mice were greater than those of the controls after bacterial challenge. Moreover, pretreatment with GH or IGF-I improved clearance of <I>E. coli</I> from the peritoneal cavity. GH and IGF-I increased CD11b and CD32/16 expression on peritoneal exudative neutrophils. These hormones directly enhanced the <I>E. coli</I> killing activity of murine peritoneal exudative cells <I>in vitro</I>. In this <I>E. coli</I> peritonitis model, GH and IGF-I both primed exudative phagocytes for enhanced production of cytokines, tumor nectosis factor (TNF), interleukin-1 (IL-1) and IL-6. Pretreatment with either GH or IGF-I also enhanced the capacity of plasma to support the <I>in vitro</I> bactericidal activity of peritoneal exudative cells. This suggests that GH and IGF-I improve host defense against infection.
- 日本小児内分泌学会の論文
日本小児内分泌学会 | 論文
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