A Case of Stunted Growth Caused by Glucocorticoid Ointment Treatment for Psoriasis Universalis
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概要
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Stunted growth has been rarely reported as a side effect of treatment with glucocorticoid ointment. We report a 14-year-old boy who visited our clinic complaining of short stature. Since 9 years of age, he had been treated for psoriasis universalis with bethamethasone ointment by a dermatologist. The dosage of the ointment was approximately 30g/week, i. e. 4-5g/day. At the first visit, cushingoid features were noted as well as short stature (-2.9 SD). Serum cortisol concentrations were very low (1.0-1.7μg/dL) and their diurnal variation had disappeared. Administration of ACTH demonstrated a failure of the cortisol response. Urinary 17-OHCS and 17-KS were 0.8 and 2.2mg/day, respectively. From these data suppression of the pituitaryadrenocortical axis was obviously present in this patient. A diabetic pattern was also observed by an oral glucose tolerance test. After reducing the dosage, the response of cortisol to exogenous ACTH recovered to some extent. However, plasma ACTH remained low in a CRF test.
- 日本小児内分泌学会の論文
日本小児内分泌学会 | 論文
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