Effect of Human Growth Hormone (GH) Therapy on Non-Endocrine Short Stature (NESS) Compared with GH Deficient Children and Factors which Predict the Response to GH Therapy
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The effect of human growth hormone treatment was studied on 11 prepubertal NESS children compared with six GH deficient (GHD) children (3 partial GHD, 3 GH neurosecretory dysfunction (GHNSD)). All patients were evaluated after 6 months to 1 year of treatment. Height velocity (HV), height SD (HSD) and height velocity SD score for chronological age (HV SDSCA) increased statistically significantly (p<0.05) in both groups. Predicted adult height did not change significantly in both groups (NESS: 154.6cm vs. 156.5cm, n=7, GHD: 154.8cm vs. 157.1cm, n=3). δHV SDSCA correlated significantly with HV (r=0.67, p=0.03) and HV SDSCA (r=0.72, p=0.001) but not with nocturnal GH secretion, urinary GH secretion and stimulated peak serum GH level. δBA/δCA and δHA/δCA of NESS and GHD were 0.88±0.49 and 1.84±1.36, n=7, 1.84±1.36 and 0.89±0.5, n=3, respectively.<BR>NESS children responded equally well to GH treatment as GHD children did; auxological parameters affect the response to GH treatment.
- 日本小児内分泌学会の論文
日本小児内分泌学会 | 論文
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