Altered Sequence of Pubertal Changes and Accelerated Bone Maturation in A 10-Year-Old Japanese Boy with Nonendocrine Short Stature Treated with GH.
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概要
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A 10-year-old Japanese boy with nonendocrine short stature who was treated with GH showed discordant pubertal development and advanced skeletal maturation. GH therapy was started at 6.8 years of age at a dose of 0.5u/kg/week, when his height age was 3.3 years and bone age was 4.8 years. At 10.3 years of age his height and bone age reached 7.5 and 9.0 years, respectively, but unexpectedly he developed pubic hair (Tanner stage II, with a testicular volume of 4mL). It appears that the pharmacological dose of GH prematurely induced Leydig cell activity in this patient.
- 日本小児内分泌学会の論文
日本小児内分泌学会 | 論文
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