Growth Hormone-Binding Protein Measurements in Normal Children and Children with Short Statute Using Ligand-Mediated Immunofunctional Assay
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To investigate the role of growth hormone (GH) and its downstream axis in normal growth and growth disorders, we measured serum GH-binding protein (GHBP) levels in normal children and children with short stature by ligand-mediated immunofunctional assay (LIFA). Samples were obtained from 512 healthy children with normal stature, 146 5-day-old healthy neonates, and 153 short children with normal GH secretion (normal short children). Serum GHBP showed significant correlation with percent overweight (r=0.71, P<0.01) in normal children. Diurnal variations in serum GHBP were scarcely observed. Serum GHBP levels were low in neonates, rose acutely within 6 months, and gradually increased toward pubertal age in normal children (r=0.2, P<0.01, assessed among subjects over 1 year old). Neither significant sex differences nor rapid peaked changes during puberty were observed. In normal short children, GHBP levels were lower than in normal controls.<BR>These data suggest resistance to GH or low efficacy of GH utilization could be one of the etiologies of growth disorder in normal short children.
- 日本小児内分泌学会の論文
日本小児内分泌学会 | 論文
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