Growth Hormone Deficiency in a Patient with Mid-Line Anomalies: Case Report
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概要
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Mid-line developmental defects have been reported in association with growth retardation with or without growth hormone deficiency.<BR>A boy aged seven years eight months was referred for the evaluation of frequent upper respiratory infections and pulmonary hypertension. He was diagnosed as having micrognathia and microglossia at birth. Because of respiratory distress and impairment of swallowing, he had received a tracheostomy and assisted ventilation as well as a gastrostomy. Physical examination showed his height was 98.1cm (-4.5SD) and he weighed 15.0kg (-2.5SD). The bone age was delayed at four years six months, as evaluated by the G&P method. The plasma somatomedin-C level was low (0.66U/ml). Growth hormone deficiency was thought possible by his growth curve, and endocrinological studies were performed. The results were as follows: normal thyroid function; reduced response of growth hormone to stimulation tests (ITT 1.49→4.77ng/ml, ATT 1.32-2.71ng/ml).<BR>Growth hormone secretion should be evaluated in children with mid-line developmental anomalies and short stature.
- 日本小児内分泌学会の論文
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