The Response of Insulin-like Growth Factor Binding Protein-3 Complex to Growth Hormone
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概要
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Biochemical markers of response to growth hormone (GH) have been determined by many groups for use as long term predictors of growth response. We have examined the changes in insulin-like growth factor binding protein (IGFBP) -3 by RIA in three groups of children (biochemical GH Deficiency (GHD, n=36), Chronic Renal Failure (CRF, n=22), Idiopathic Short Stature (ISS, n=101)) during six months treatment. Additionally, the alpha subunit of IGFBP-3 (ALS) was measured in the last group. Ten GHD children showed during the first 24 hours a mean IGFBP-3 increase of 37% and this change strongly related to the change in the sum of IGF<SUB>1</SUB> + IGF<SUB>11</SUB> (r=0.882). The change at three and six months for the GHD group was variable and did not relate to an individual's growth response. IGFBP-3 was high in CRF group at baseline and did not rise during therapy. Both mean IGFBP-3 and ALS showed a dose dependent rise when two doses of GH were given for six months in ISS group but this change was less than seen with mean IGF<SUB>1</SUB> and could not be used to confidently predict subsequent growth response. These studies confirm the GH dependence of IGFBP-3 but its routine measurement for prediction of future growth is not indicated.
- 日本小児内分泌学会の論文
日本小児内分泌学会 | 論文
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