Sporadic Testotoxicosis in Japanese Children: Report of 4 Cases
スポンサーリンク
概要
- 論文の詳細を見る
Familial testotoxicosis is a gonadotropin-independent autosomal dominant condition in which precocious puberty occurs, only in males. We present the cases of four Japanese boys with precocious sexual development aged 3 to 4 years, who showed pubertal serum testosterone levels, but with low basal serum gonadotropin levels and a minimal response of gonadotropins to luteinizing hormone releasing hormone. They showed symmetric testicular enlargement, premature Leydig cell maturation and spermatogenesis. There was no evidence of familial sexual precocity in three generations. These findings are consistent with familial testotoxicosis except for the negative family history. In a nationwide survey for precocious puberty in Japan, there were no familial cases of male-limited sexual precocity. It appears that this disease is limited to sporadic cases and is very rare in Japan.
- 日本小児内分泌学会の論文
日本小児内分泌学会 | 論文
- 43 Common origin of the Q258X mutation in StAR gene responsible for congenital aderenal lipoid hyperplasia in Japanese
- Recent Change in the Annual Incidence of Childhood Type 2 Diabetes in the Tokyo Metropolitan Area
- A Case of Acute Lymphoblastic Leukemia with Prader-Willi Syndrome during Growth Hormone Therapy
- Characteristics of a Fulminant Onset Form of Idiopathic Type 1 Diabetes Mellitus in Japanese Children
- Different Skeletal Phenotypes in a Mother and Two Daughters with Short Stature Homeobox-Containing Haploinsufficiency