Relationship among Blood Lactate and Plasma Catecholamine Levels during Exercise in Acute Hypoxia.
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Five male subjects performed steady exercise on a cycle ergometer at an intensity of 60% maximal 0<SUB>2</SUB> uptake (V0<SUB>2</SUB>max) for 6 min on three separate occasions while breathing gas mixtures of 12, 16 or 21% 0<SUB>2</SUB> in N<SUB>2</SUB> Expired gas fractions, ventilation, heart rate, arterial 0<SUB>2</SUB> saturation (Sa0<SUB>2</SUB>), blood lactate (La) and plasma catecholamines (epinephrine: E and norepinephrine: NE) were measured. 0<SUB>2</SUB> uptake (V0<SUB>2</SUB>) was calculated for the last minute of exercise. Blood samples were drawn at rest and immediately after exercise. By inspiring hypoxic gas mixtures, the Sa0<SUB>2</SUB> value decreased during exercise to 85.0±5.4 (16%) and 66.4±4.1 (12%) from 95.0±0. 1 in normoxia. V0<SUB>2</SUB> during exercise was not different among the three conditions. Exercise-induced La accumulation was increased by hypoxia. E and NE during exercise were not affected by hypoxia statistically. There was a significant correlation between La and E (P<0.01) and between La and NE (P<0.01) during exercise in the three conditions. The present findings suggest a relationship between glycogen metabolism and sympathoadrenal activity which results in an increase of plasma catecholamines during exercise in humans acutely exposed to hypoxia.
- 日本生理人類学会の論文
日本生理人類学会 | 論文
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