尿路感染症に対するCefotetan(YM09330)の臨床的評価 (Cefotetan(CTT,YM09330)<特集>)

概要

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The in vitro antibacterial activities, the distribution in human prostatic fluids, the clinical effects and the side effects of new cephamycin derivative, cefotetan (CTT, YM09330), were studied. The in vitro antibacterial activities of cefotetan were examined each five strains of E. coli and K. pneumoniae. The MICs against those strains were in the range of ≤0.2-0.39μg/ml and 2-3 tubes superior than those of cefmetazole. The concentration in human prostatic fluids was 0.55μg/ml in average one hour after, with one gram i. v, administration and the relative concentration to that of serum was 0.008. Fifty cases were clinically examined and most of doses were one g/day (once or divided in two) with intravenous injection. The evaluated 36 cases with complicated urinary tract infections gave the effective rate of 69.4% and 8 cases with simple urinary tract infections did the result of 100%. Among three cases of urethritis, two gonorrheal cases yielded excellent results and the other non-gonorrheal case resulted poor. As side effects, one case of vomiting and another case of fever were observed and as abnormal laboratory findings, one case showed slight elevation of GOT, however they recovered rapidly after the cessation of the drug administration.
公益社団法人日本化学療法学会の論文