Effect of Extensive Surgery in Multidisciplinary Therapy for Malignant Astrocytoma
スポンサーリンク
概要
- 論文の詳細を見る
Ten patients who had undergone surgery for malignant astrocytoma were studied to evaluate the effect of immunochemoradiation therapy on postoperative tumor volume. The patient's average age was 64.8 years, and the mean preoperative Karnof sky performance rating was 76%. Eight patients had glioblastoma and two patients had anaplastic astrocytoma. Tumor volumes before and after surgery were compared using computer tomographic and magnetic resonance imaging scans with contrast enhancement and a micro-computer-assisted image analysis system. In five patients, tumor volume decreased or was unchanged (effective group), and in another five patients tumor volume increased (ineffective group) . The proliferative activity of the tumor was examined by staining of argyrophilic nucleolar organizer regions (AgNORs) . The mean number of AgNORs was 2.67 in the effective group and 2.61 in the ineffective group. Differences between the two groups in preoperative tumor volume, residual tumor volume, survival time, mean number of AgNORs, and the percentage of nuclear area occupied by AgNORs (% A/N) were examined by the Mann-Whitney U test. There was no significant difference between the two groups in proliferative potential. Only postoperative residual tumor volume was significantly different between the two groups (p<0.05) . In the effective group the postoperative tumor volume was less than 10 cm<SUP>3</SUP>. Therefore, extensive surgery in which postoperative residual tumor volume is less than 10 cm<SUP>3</SUP> may increase the efficacy of postoperative immunochemoradiation therapy and may be the most important component of the same multidisciplinary therapy.
- 昭和大学・昭和医学会の論文
昭和大学・昭和医学会 | 論文
- 病理検体（ホルマリン固定パラフィン包埋組織切片）を用いた感染症遺伝子診断：結核菌Mycobacterium tuberculosis
- リンパ形質細胞性リンパ腫 / Waldenströmマクログロブリン血症
- 大学での30年間を振り返り
- 摂食・嚥下障害のリハビリテーションその包括的対応
- 原発性肝癌肝切除後の根治的治療不能残肝再発例に対するCDDP+5-FUによる肝動注療法の経験 : ―静止療法としての抗腫瘍効果と副作用―