Clinical Significance of Serum Bile Acid Fraction in Liver Diseases as Analyzed by Enzyme-linked Immunosorbent Assay
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A method of enzyme-linked immunosorbent assay (ELISA) has been established for fractions of cholic acid (CA), chenodeoxycholic acid (CDCA), deoxycholic acid (DCA), and ursodeoxycholic acid (UDCA) . With this method we have obtained serum bile acid fractions of 307 healthy individuals and 37 patients with liver disease; 6 cases of acute hepatitis (AH), 13 cases of chronic hepatitis (CH), 13 cases of liver cirrhosis (LC), and 5 cases of hepatocellular carcinoma (HCC) . Using these fractions, we then calculated the ratios of CA/CDCA, CDCA/DCA, CA/DCA, CA+CDCA/DCA, and CA+CDCA/ DCA+UDCA. Further, we have set up reference values from healthy individuals, and then studied the clinical significance of each componential ratio for each liver disease group. The fraction of each bile acid, especially CDCA, DCA, and UDCA, showed an abnormally high value in all liver diseases. With respect to componential ratios, the CA/CDCA ratio was recognized to be within reference values of healthy individuals in almost all liver diseases. However, among LC patients, the ratio was significantly higher than that of healthy individuals. With respect to the CDCA/DCA ratio, the number of abnormal cases was the smallest among AH patients, followed by CH patients, LC patients, and HCC patients in the ascending order. This tendency appears to suggest qualitative differences in these liver diseases. A similar tendency was found in the ratio of CA+ CDCA/DCA, although it was not as significant as the CDCA/DCA ratio. The above results indicate that the method which enables us to obtain serum bile acid fractions and their componential ratios of CDCA/DCA and CA+CDCA/ DCA provides useful information on the pathophysiological analysis and prognostic observations of liver disease.
- 昭和大学・昭和医学会の論文
昭和大学・昭和医学会 | 論文
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