Pioglitazone Modulates Plasma MMP-9 and TIMP-1 Activities in Spontaneously Hypertensive Hyperlipidemic Rats Fed a High-fat Diet Plus Sucrose Solution
スポンサーリンク
概要
- 論文の詳細を見る
Atherosclerosis is accelerated when it occurs concomitantly with hypertension and hyperlpidemia. We derived a spontaneously hypertensive hyperlipidemic rat (SHHR) by cross-breeding. SHHR represents a good model of vascular degeneration, particularly when the rats are fed a high-fat diet supplemented with a sucrose solution (SHHR-HFDS) . Matrix metalloproteinases (MMPs) and the tissue inhibitor of metalloproteinases (TIMPs) play important roles in atherosclerosis. Peroxisome proliferator-activated receptor-γ (PPAR-γ) agonists (thiazolidinediones), such as pioglitazone, decrease plasma MMP-9 expression in type 2 diabetic patients. However, the effects of pioglitazone on MMP-9 and TIMP-1 in atherosclerosis without diabetes are not clear. We investigated the effects of pioglitazone on the activities of MMP-9 and TIMP-1 in the plasma of SHHR-HFDS. Male SHHRs were fed a normal diet for 4 months, and then administered N<SUP>G</SUP>-nitro-L-arginine methyl ester (L-NAME) for 1 month, followed by a high-fat diet (2% cholesterol, 1% cholic acid, 5% coconut oil) and a 15% sucrose solution <I>ad libitum</I> for an additional 2 months. Pioglitazone (3 or 10 mg/kg/day subcutaneously) was co-administered with HFDS for 2 months. Aortic lipid deposition increased clearly in the SHHR-HFDS group at 7 months of age. Pioglitazone decreased aortic lipid deposition and plasma MMP-9 activity, but increased plasma TIMP-1 activity in the SHHR-HFDS group, as compared with the non-treated SHHR-HFDS group. These results suggest that pioglitazone decreases lipid deposition partly by modulating MMP-9 and TIMP-1 activities.
- 昭和大学・昭和医学会の論文
昭和大学・昭和医学会 | 論文
- 病理検体（ホルマリン固定パラフィン包埋組織切片）を用いた感染症遺伝子診断：結核菌Mycobacterium tuberculosis
- リンパ形質細胞性リンパ腫 / Waldenströmマクログロブリン血症
- 大学での30年間を振り返り
- 摂食・嚥下障害のリハビリテーションその包括的対応
- 原発性肝癌肝切除後の根治的治療不能残肝再発例に対するCDDP+5-FUによる肝動注療法の経験 : ―静止療法としての抗腫瘍効果と副作用―