A Clinicopathological Study of Gastric Cancer Patients with Intestinal Resection for Peritoneal Metastasis: Relationship between Lymphatic Advancement and Peritoneal Metastasis

概要

論文の詳細を見る
By investigating the lymph retention state in a rat model we previously demonstrated the reflux flow of cancer cells into the mesenteric lymph vessels and the subsequent presence of these cells in the intestinal wall. Here, as a clinical model of this phenomenon, we analyzed the resected intestines of gastric cancer patients. We examined eight cases of combined intestinal resection for peritoneal metastases of gastric cancer (primary group) and five cases of peritoneal recurrence (recurrent group) . In addition to clinicopathological investigations of the primary gastric cancer, we investigated the pathology of resected intestines according to the area of cancer cell invasion in the intestinal wall. In the primary group, cancer invasion of the intestinal wall was found in the extraserosa in five cases, and in the remaining three cases, cancer invasion had reached the proper muscle layer. In the recurrent group, the cancer invasion had reached every layer of the intestinal wall. The relationship between the area of cancer invasion in the intestinal wall and the peritoneal metastatic foci suggests that cancer cell invasion of the intestinal wall occurs via the lymph system.
昭和大学・昭和医学会の論文