Relationship between Malignant Transformation of Endometriosis and Genetic Alterations of K-ras and Microsatellite Instability

概要

論文の詳細を見る
Several genetic alterations have been associated with the malignant transformation from endometriosis to ovarian cancer. However, the role of each genetic alteration in this multi-step process of tumorigenesis has not been clarified. Regions of endometriosis, atypical endometriosis, and ovarian endometrioid carcinoma were separated by laser microdissection, and examined for the presence of K-ras mutation and microsatellite instability. K-ras mutation and microsatellite instability were detected in endometrioid carcinoma tissue, but not in endometriosis and atypical endometriosis bordering the cancerous region. K-ras mutation and microsatellite instability may be associated with the malignant transformation from atypical endometriosis to ovarian endometrioid carcinoma, but not from endometriosis to atypical endometriosis.
昭和大学・昭和医学会の論文