A Case of Malignant Endocrine Tumor of the Stomach that Responded to Chemotherapy

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A combination of cis-Dichlorodiammineplatinum (CDDP) and 5-fluorouracil (5-FU) may be used to treat gastric carcinoma and a combination of CDDP and 5'-deoxy-5-fluorouridine (5'-DFUR) is a safe and effective outpatient treatment for advanced gastric carcinoma. However, malignant endocrine tumors of the stomach such as carcinoid and endocrine cell carcinoma rarely respond to the CDDP and 5-FU combination. We treated a gastric carcinoma patient with CDDP and 5'-DFUR. Primary and metastatic lesions decreased markedly and a total gastrectomy was possible. HE staining showed that medium-sized, spindle-shaped carcinoma cells with a high N/C ratio had proliferated, to form a solid tumor. There was a massive necrotic area in the tumor, possibly the effect of chemotherapy. Grimelius staining showed argyrophilia in tumor cells, but Fontana-Masson stain was negative. Thus, this case was diagnosed as malignant endocrine cell carcinoma of the stomach.
昭和大学・昭和医学会の論文