Possibility of Antiseptic Formula Employing Pionin Combination with 1,2-Pentanediol in the Cosmetic Field

概要

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It has been reported that parabene, the most frequently used antiseptic in the cosmetic field, has adverse effects. We have evaluated bacteriologically whether Pionin could be used in place of parabene as an antiseptic agent. When Pionin was added to various commercially available cosmetics, it exerted potential antimicrobial activity. In a lotion, Pionin in combination with 1, 2-pentanediol exceeded parabene in the antimicrobial activity. Furthermore, a cream containing no parabene but containing Pionin and 1, 2-pentanediol fulfilled the requirements of antiseptics in The Japanese Pharmacopeia (14th edition) adequately. When the cream was applied to brachial arm skin of healthy men and women at 24h intervals for 7 days, the total aerobic and anaerobic bacterial numbers of skin micro-flora were not significantly different from those of control (without creamapplication). Therefore, Pionin together with 1, 2-pentanediol might be a novel antiseptic formula in cosmetics having less bactericidal activity to skin micro-flora.
日本化粧品技術者会の論文