Development of an Automated Routine Analysis System for Cosmetic Products Using 13C-NMR Spectroscopy and HPLC-Retention Index(RI).
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概要
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We have developed an automated routine analysis system for cosmetic products, which is designed to obtain information on as many ingredients as possible with a simple pretreatment and through a single analysis. 13C-NMR spectroscopy and liquid chromatography (LC) have been employed for analyses of base ingredients and additives, for each of which an automated retrieval system from a custom-modified database was established with commercially available software by using as retrieval parameters chemical shifts and a combination of retention index (RI) and absorbance ratio at two wavelengths, respectively. The system has been proved to be rapid, simple to operate, and sufficiently accurate for practical purposes.
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