Application of Fast Atom Bombardment Ionization-Mass Spectrometry(FAB-MS) to Cosmetic Analysis.

概要

論文の詳細を見る
An optimized FAB-MS measurement method has successfully been incorporated into the systematic analysis method of cosmetic products based upon a stepwise elution silica-gel column chromatography as a skeleton fractionation method and a combined use of 13C-NMR and GC/MS. The system was able to precisely identify the components such as polyoxyalkyleneglycol, oxyalkylated nonionic surfactants, polyglycerin and its derivatives, etc. for their alkyl and/or oxyalkylene chain distributions, which are eluted in the acetone and methanol fractions in silica-gel column chromatography. A simulation was carried out for various cosmetic ingredients based upon the results of spectral analysis and it was constructed in a simple retrieval system using a database of the numerical values and chemical structures. Reflection of a mixture state to the spectrum has been studied semi-quantitatively including an optimization of measuring conditions.
日本化粧品技術者会の論文