Skin sensory stimulation. (The second report). Measurement of dermal sensory irritation caused by application of cosmetic ingredients.:Measurement of dermal sensory irritation caused by application of cosmetic ingredients
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概要
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Skin sensory irritation is one of the safety evaluations of cosmetic Products. This irritation problem seldom gives rise to consumer complaints, because it is the passing and subjective stimulation without objective responses. However, in our opinon, the irritation problem is very important, because it will influence cosmetic selection and usage. Accordingly, we investigated an objective measuring method of the skin sensory irritation induced by application of chemical agents.We used an electricencephalograph in our measuring method for the pain-related positive component (P250). All our studies were performed after obtainning the imformed consent from volounteers. Primarily, 45 subjects were screened by means of investigation for sensory sensitivity against the application of chemical agents. Then two groups of five each were selected, one group was composed of hypersensitive subjects and another group was composed of low sensitive subjects.Secondly, the electric potential evoked by electric stimulation on the skin of the middle finger was measured as a reference without any application of a chemical agent. It showed a positive variation approxymately 250msec after electric stimulating, which is so-called P250 and is the exact represented intensy of sensory irritation. Then the intervention against P250, only of the electric stimulating, was investigated with an application of a 3% citric acid solution, which is the causative agent of chemical sensory irritation. In results, two findings were obtained as follows.1) Amplitudes of the hypersensitive subjects were significantly smaller than that of the low sensitive subjects at 1% confidential level.2) In the hypersensitive subjects, when the citric acid solution was applied on the skin of the face, the amplitudes of "P250" decreased significantly at 5% confidential level, resulting in the intervention against the electric stimulating.The abovementioned two findings suggest that this measuring method is useful for objective evaluation of the sensory irritation induced by application of chemical agents.
- 日本化粧品技術者会の論文
日本化粧品技術者会 | 論文
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