Management of a pregnant woman with familial hyperlipidemia; a case report.

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During normal gestation, maternal hormonal changes have a significant influence on maternal metabolism. For example, an increase in maternal serum lipid is thought to be important for fetal glucose supply. However it may be necessary to control a pathological increase in serum lipid in pregnant women with familial hyperlipidemia. We present a case of familial hyperlipidemia who was treated during gestation. The patient was a 32-year-old woman with familial hyperlipidemia, who needed to take hypocholesterolemic agents before pregnancy. She ceased taking the medicine because of her pregnancy. She was followed up from the 7 weeks' gestation. Because of a rapid increase in serum lipid levels before the 21st week, hypocholesterolemic agents were required. At the 38 weeks' gestation, the patient underwent caesarean section because of cepharo-pelvic disproportion. The neonate was normally grown with an almost normal serum lipid level. Familial hyperlipidemia is often observed, but it is unclear how it influences maternal and fetal outcomes. We discuss here whether hyperlipidemia during gestation should be treated or not. Since pregnancy accompanied by hyperlipidemia is not rare, the influence of hyperlipidemia on gestation warrants further study. [Adv Obstet Gynecol 52 (2); 139 142, 2000 (H.12.3)]
近畿産科婦人科学会の論文