Evaluation of inhibin A concentration in maternal serum between 13 and 17 weeks of gestation.

概要

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Inhibin is produced by the syncytiotrophoblast of human placenta during pregnancy and is composed of one a -subunit and one of two related 13 -subunits (inhibin A: a - /3 A or inhibin B: a l3 B). Several foreign studies have shown that maternal serum inhibin A levels are raised on average in second trimester pregnancies affected with Down's syndrome. The purpose of this study was to investigate dimeric inhibin A concentration in the second trimester for normal Japanese pregnancies. Additionally we examined the distribution of inhibin A concentration in Down's syndrome pregnancies. The results indicated almost no variation of the median value across the 146 to 16th week of pregnancy. As negative correlation was observed between concentration of inhibin A and maternal weight, the median MoM should be corrected by the weight of each pregnant woman. Significant correlation was observed between inhibin A and hCG concentration. The increase in the serum concentration of inhibin A from women with affected by Down's syndrome was observed, although the number of pregnancies affected was limited. [Adv Obstet Gynecol 52 (1); 6 13, 2000 (H.12.1)]
近畿産科婦人科学会の論文