A case of severe polymyositis occurring during pregnancy.
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Polymyositis (PM) is collagen disease that affects striated muscle. We present a case of polymyositis occurring during pregnancy. The patient was a 27-year-old pregnant woman (gravida 1, para 1). She had neither a past nor a family history of collagen disease. At 14 weeks of gestation, she complained of myalgia, muscle weakness in all extremities, and gross hematuria, and was admitted to our hospital. The laboratory data revealed extreme elevation of creatinine kinase (CK) in serum (43, 560IU / 1). The findings of an electromyogram showed a myogenic pattern. The diagnosis of polymyositis was made from these findings and 60mg / day of prednisolone was started. The laboratory findings and clinical symptoms improved dramatically and the disease was inactive during the rest of the pregnancy by prednisolone treatment. A healthy male infant weighing 2880g was born at 37 weeks of gestation without prolonged labor, and the clinical course after delivery was unremarkable. In the literature, it is reported that the risk of intrauterine growth retardation, intrauterine fetal death or neonatal death in pregnancies complicated with PM is higher than that in normal pregnancies. Additionally, some cases are active or exacerbated during pregnancy even though corticosteroid therapy is administered. Therefore, pregnancies associated with PM should be managed carefully. In this case, maternal and fetal outcomes were successful because of a good response to corticosteroids. The successful management of polymyositis occurring during pregnancy could be dependent on the response to corticosteroid therapy. [Adv Obstet Gynecol 51 (2); 160 164, 1999 (H11.3)]
- 近畿産科婦人科学会の論文
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