Husband's leukocyte immunization for unexplained recurrent aborters.

概要

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We investigated 79 patients, who had repeatedly aborted for unknown causes, as to their pregnancy and neonatal outcomes after they had been immunized with their husbands' leukocytes. After the immunotherapy, 65 cases resulted in pregnancy, and in 50 (76.9 %) abortion could be prevented. Among the 47 live birth, there was one case with severe preeclampsia, and two cases with maternal hepatic dysfunction, although no specific maternal complications due to the immunotherapy were identified. Neither were there any specific neonatal complications attributable to the immunotherapy but a rare case of transient neonatal thrombocytopenia resulting from maternal anti-HLA antibody was found among the 48 neonates. Five subjects experienced subsequent spontaneous pregnancy without any additional immunotherapy, and four of them resulted in live births. Allogenic leukocyte immunization for women who repeatedly abort for unknown reasons can therefore be generally considered to be safe and to induce very few specific complications. [Adv Obstet Gynecol 49 (4); 383-386, 1997 (H9.7)]
近畿産科婦人科学会の論文