Case report: Surface serous peritoneal adenocarcinoma(SSPC) with a complete response to chemotherapy with CDDP.
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The patient was 53-year-old woman who had undergone four pregnancies and had one child. She had been hypertensive for one year. The chief complaint was abdominal distention, and ascites with positive cytology was noted. There was no remarkable primary lesion on ultrasonography or MR imaging. We suspected ovarian cancer or SSPC, and she was given neo-adjuvant CAP chemotherapy, CDDP(80mg/body) by intraperitoneal injection, ADM(50mg/body) and CPM(400mg/body) by intravenous injection. Soon after she completing one course chemotherapy, ascites was significantly reduced, and laboratory data showed that serum CAl25 had decreased from 1600 to 180 U/ml and that serum TPA was reduced from 390to 110 U/1. After completing three courses of chemotherapy, the patient underwent surgery. Simple total hysterectomy with bilateral salpingo-oophorectomy, omentectomy and pelvic and paraaortic lymph node resection were performed. At surgery, both ovaries were normal in size and shape. Ascites was slight, but there were many small papillous tumors about the size of a red bean in the omentum, right mesosalpinx, vesicouterine peritoneum, cul-de-sac, and caecum. Histological diagnosis was surface serous peritoneal adenocarcinoma. Clinical stage was III c (FIGO). After surgery, she was given 6 more courses of the same chemotherapy. The patient has survived without evidence of disease for 38 months to date. [Adv Obstet Gynecol 49 (2); 116.119, 1997 (H9.3)]
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