Infection of human herpesvirus-6(HHV-6) in pregnancy and its relevance to spontaneous abortion.
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Human herpesvirus-6 (HHV-6) which was detected in peripheral blood lymphocytes of lymphocytic patients is now said to be an agent causing exanthema subitum. I have examined the effect of HHV-6 infection in early pregnancy. Serum HHV-6 IgG and IgM antibodies were assayed in 202 primigravidas and 61 patients with spontaneous abortion in weeks 6-12 of pregnancy by means of the indirect immunofluorescence (IF) method. The incidence of positive reaction in which the titer of HHV-6 antibody was more than 10 times was 86.6% in 202 primigravidas. That of HHV-6 IgM antibody was 2.5%. In 61spontaneous abortion patients, 90.2% was positive for HHV-6 antibody. Five of them had IgM antibody to HHV-6. Villous tissue was collected in the patients with spontaneous abortion was examined to HHV-6antigen. IIIIV-6 antigen was detected on the epithelium of the chorionic villous tissue by IF method using HHV -6 positive serum and III-IV-6 monoclonal antibody in 4 of the 5 IgM positive patients. The reaction was specific to FIHV-6 antibody. Not antigen to CMV, I-ISV-1, HSV-2, EBV, and rubella antigen were not could observed there. Change such as swollen symplasts and slight degenerations were revealed by staining with haematoxylin and eosin. I-Ierpesvirus-like particles were observed there with electron microscopy. Immune electron microscopy showed reactivity to HHV-6 on them. From these observation, it was suggested that the first infection with or reactivation of HHV-6 might predispose early pregnant women to spontaneous abortion. [Adv Obstet Gynecol 48 (4); 396-405, 1996 (H8.7)]
- 近畿産科婦人科学会の論文
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