Altered maternal calcium homeostasis during pregnancy in streptozotocin-induced diabetic rats.

概要

論文の詳細を見る
To assess the effect of maternal hyperglycemia on calcium metabolism in an animal model, we evaluated calcium homeostasis during pregnancy in diabetic rats. In streptozotocin-induced diabetic rats, maternal blood glucose level was controlled by daily injection of NPH insulin or saline from day 3 to 21of pregnancy. Serum concentrations of ionized calcium, calcium-regulating hormones and intestinal calcium absorption were measured on day 21 of pregnancy. No correlation was noted between serum ionized calcium concentration and maternal mean blood glucose (MBG). Serum concentrations of la, 25(OH)2 vitamin D3 and intestinal calcium absorption were negatively correlated with MBG. A marked proliferation of the duodenal villi were demonstrated as hyperglycemia progressed. Serum concentrations of PTH were positively correlated with MBG lower than 220mg/d1, whereas a negative correlation was observed with MBG higher than 220mg/d1. These results suggest that diabetic pregnant rats are characterized by reduction of serum 1a, 25 (OH)2vitamin D3 levels followed by decrease of intestinal calcium absorption. To maintain calcium homeostasis, PTH secretion was promoted under 220 240mg/dl of MBG, while it is suppressed over 220 240mg/dl of MBG, due in part to, by adverse effects of hyperglycemia on parathyroid gland. [Adv Obstet Gynecol 48]
近畿産科婦人科学会の論文