Elevation of serum CA-125 levels during mensruation in patients with endometriosis.

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Serum CA-125 levels were analyzed in 40 patients with sterility including 25 cases of endometriosis externa (EN) and 15 cases of non-endometriosis in order to evaluate its usefulness in the diagnosis of EN. (The diagnosis was confirmed by laparoscopy). Serum CA-125 levels during non-menstrual periods were significantly elevated only in patients with EN of stage III/IV, as compared with those in non-endometriosis. However, CA-125 levels during menstruation (days 1-2 of the menstrual cycle) exceeded 35 units/ml even early stage of EN and these were significantly higher than those in women without endometriosis. The result suggested the measurement of CA-125 during menstruation was more useful for diagnosis of EN than those in non-menstrual periods. An acception occured in 7 cases of 25 cases without endometriosis, where serum CA-125 levels during menstruation exceeded 35 units/ml.These cases supposedly complicated with peritoneal stimulations by pelvic adhesion, ascites and inflammation.<BR>Laparoscopy is still required to confirm the diagnosis of endometriosis, but, serum CA-125 level during the menstrual periods could greatly improve the usefulness of the diagnosis.
近畿産科婦人科学会の論文