Studies on the pathogenesis of cancer cachexy. Partial isolation of anemia-inducing substance (AIS) and basic study on removal of AIS by plasmapheresis.:Partial isolation of Anemia-inducing substance (AIS) and basic study on removal of AIS by plasmapheres

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Anemia-inducing substance (AIS) appears in plasma with cancer progress. As reported by us previously, AIS binds to red blood cells (RBC) and immunologically competent cells to induce cancer anemia and immunodeficiency eventually. The rationale of plasmapheresis using normal RBC is based on this character of AIS. In this study, we first clarified the properties of AIS isolated from cancer tissue by affinity chromatography and used a non-coating charcoal column to remove AIS from the cachectic plasma. The following results were obtained. 1) Isolated AIS was heat-sensitive and alkali-resistant. 2) It showed a specific peak at about 100, 000 MW by gel filtration. 3) AIS could be completely removed by 6 rounds of adsorption using a non-coating charcoal column. 4) Similar data were obtained in the experiment using VX-2 transplanted rabbits. These observations raised the possibility of plasmapheresis with a non-coating charcoal column as a new means of immunotherapy for advanced cancer.
近畿産科婦人科学会の論文