Molecular biological studies on ectopic expression of placental alkaline phospatase mRNA in neoplasmic tissue.
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Placental alkaline phospatese (P-ALP) is a glycoprotein hormone expressed mainly in term placenta. However, it has been recently reported that this hormone can also be detected in the serum of patients with gynecologic malignancies.<BR>Here, we have utilize a P-ALP cDNA specific probe to detect P-ALP mRNA exprssion in an ovarian cancer case where serum P-ALP level was elevated. The result of this experiment showed that P-ALP mRNA species roughly equivalent in size to that of P-ALP mRNA in term placenta was produced by this ovarian cancer tissue. This finding suggests that ectopic P-ALP found in the serum of patients with gynecologic malignancies are produced locally by these tissue.
- 近畿産科婦人科学会の論文
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