Studies on the pathogenesis of cancer cachexy. Production of AIS and its immunosuppressive effect.:Production of AIS and its immunosuppressive effect

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In this study we paid particular attention to anemia-inducing substance (AIS) in the plasma of tumor-bearing subjects and investigated its effects on the red blood cells (RBCs) and cellular immunity. The results are summarized below. 1. AIS appears in the blood circulation with the progression of a cancer. It binds to RBC membranes, causing changes in the physical properties of RBCs such as decreased deformability and decreased membrane osmotic resistance. Impaired RBCs are eventually taken up by the reticulo-endothelial system, especially the spleen. This process is thought to be one of the major causes of cancer anemia, which is usually observed in cancer cachexy. 2. AIS was removed from cachectic plasma by repeated adsorption with normal RBCs, and the inhibitory effect on cellular immunity decreased as AIS was removed. 3. AIS was detected in cachectic RBC membranes and monocytes by indirect immunofluorescence using rabbit anti-AIS antibody prepared by us. AIS was also detected in the tumor tissue by the PAP method using the anti-AIS antibody. 4. AIS also binds to immunologically competent cells, causing suppression of cellular immunity. These observations strongly suggest that tumor-origin AIS, which appears in the blood of patients with terminal cancer, shows cytotoxity to RBCs and immunologically competent cells and plays a role in the pathogenesis of cancer cachexy.
近畿産科婦人科学会の論文